Labrafac™ MC60 glycerol monocaprylocaprate is a water insoluble surfactant used in lipid-based formulation to increase oral bioavailability, where it acts as a solubilizer and a permeation enhancer.
Names & synonyms
| USP NF Name | Glyceryl Mono and Dicaprylocaprate |
|---|---|
| EP Name | Glycerol monocaprylocaprate (type I) |
| UNII Code (FDA) | U72Q2I8C85 |
| Preferred Substance Name (FDA) | GLYCERYL MONO AND DICAPRYLOCAPRATE |
| Handbook of Pharmaceutical Excipients | / |
| Chemical description | Consists of mono- and diglycerides of caprylic acid (C8) and capric acid (C10), the monoester fraction being predominant |
Key characteristics
| Product form | Liquid |
|---|---|
| Viscosity (mPa.s) | 120 (20°C) |
| HLB | 5 |
Main functionalities
Solubilizer of poorly-soluble APIs, intestinal permeation enhancer of poorly permeable drugs and oral bioavailability enhancer. Water insoluble surfactant used in lipid-based formulations Type I (oily solutions), Type II (SEDDS) and Type III (SMEDDS) formulations. Safety of use is inferred by precedence of use in approved pharmaceutical products.
Main formulation technologies
Lipid-based formulations
Resources
Technical documentation
Brochures
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Gattefosse brochure Selecting the best excipients to optimize drug delivery
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Gattefosse brochure Boost your drug bioavailability with Labrafac MC60
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Brochure Gattefosse Lipid-based formulations Bio-enhancers by nature
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Poster AAPS 2023 In vivo confirmation of the permeation enhancement capacity of Labrafac MC60
Associated content
Lipid-based formulations
Lipid-based formulations are a powerful tool to increase oral bioavailability of…
Excipients for solubility and bioavailability enhancement
Poor solubility, poor permeability, and pre-systemic elimination are factors that…
Capsule filling and molding
Capsule filling and molding are common technologies suitable for powder, liquid,…